{"id":977,"date":"2026-04-12T13:00:39","date_gmt":"2026-04-12T05:00:39","guid":{"rendered":"https:\/\/longevityforesight.com\/?p=977"},"modified":"2026-04-12T13:00:40","modified_gmt":"2026-04-12T05:00:40","slug":"%e6%96%b0%e5%9e%8b%e6%8a%97%e8%a1%b0%e8%80%81%e7%94%9f%e7%89%a9%e6%a0%87%e5%bf%97%e7%89%a9protfi%ef%bc%9a%e9%80%9a%e8%bf%87%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%bb%84%e5%ad%a6%e7%b2%be%e5%87%86%e9%a2%84","status":"publish","type":"post","link":"https:\/\/longevityforesight.com\/?p=977","title":{"rendered":"\u65b0\u578b\u6297\u8870\u8001\u751f\u7269\u6807\u5fd7\u7269ProtFI\uff1a\u901a\u8fc7\u86cb\u767d\u8d28\u7ec4\u5b66\u7cbe\u51c6\u9884\u6d4b\u8870\u5f31\u4e0e\u5bff\u547d\u8d70\u5411"},"content":{"rendered":"\n<p>\u4e3a\u4e86\u6355\u6349\u4e2a\u4f53\u8870\u8001\u901f\u5ea6\u7684\u5f02\u8d28\u6027\uff0c\u4eba\u4eec\u5f00\u53d1\u4e86\u8bb8\u591a\u5206\u5b50\u8870\u8001\u751f\u7269\u6807\u5fd7\u7269\u3002\u7136\u800c\uff0c\u5bf9\u8fd9\u4e9b\u751f\u7269\u6807\u5fd7\u7269\u80cc\u540e\u7684\u6a21\u578b\u9009\u62e9\u8fdb\u884c\u7cfb\u7edf\u6027\u6bd4\u8f83\u7684\u7814\u7a76\u5374\u5341\u5206\u6709\u9650\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u5229\u7528\u82f1\u56fd\u751f\u7269\u94f6\u884cOlink\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\uff081H-NMR\uff09\u6570\u636e\uff08n = 40,696\uff09\uff0c\u57fa\u4e8eRockwood\u8870\u5f31\u6307\u6570\uff08FI\uff09\u548c\u5168\u56e0\u6b7b\u4ea1\u7387\u8bad\u7ec3\u4e86\u8870\u8001\u751f\u7269\u6807\u5fd7\u7269\u6a21\u578b\u3002\u6211\u4eec\u7cfb\u7edf\u5730\u7814\u7a76\u4e86\u6a21\u578b\u9009\u62e9\u3001\u76ee\u6807\u7ed3\u5c40\u548c\u5206\u5b50\u6570\u636e\u6765\u6e90\u5bf9\u591a\u79cd\u5e74\u9f84\u76f8\u5173\u7ed3\u5c40\u7684\u5f71\u54cd\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u6211\u4eec\u5f00\u53d1\u4e86\u4e24\u79cd\u8870\u8001\u751f\u7269\u6807\u5fd7\u7269\uff1aProteinFrailty\uff08ProtFI\uff09\u548cProteinMortality\uff08ProtMort\uff09\u3002\u8fd9\u4e24\u79cd\u6a21\u578b\u5747\u4e3aElasticNet\u6a21\u578b\uff0c\u5206\u522b\u4f7f\u7528\u4e00\u7ec4\u6700\u5c0f\u7684\u86cb\u767d\u8d28\u6765\u9884\u6d4bFI\u548c\u6b7b\u4ea1\u7387\u3002\u5c24\u5176\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cProtFI\u5728\u9884\u6d4b\u591a\u79cd\u7ed3\u5c40\u65b9\u9762\u5747\u4f18\u4e8e\u5df2\u6709\u7684\u8870\u8001\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5305\u62ec\u65b0\u53d1\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u63e1\u529b\u4ee5\u53ca\u81ea\u8bc4\u5065\u5eb7\u72b6\u51b5\uff0c\u65e0\u8bba\u662f\u5728\u5185\u90e8\u9a8c\u8bc1\u8fd8\u662f\u5728\u4e24\u4e2a\u8377\u5170\u5916\u90e8\u961f\u5217\uff08n = 995\uff0cn = 500\uff09\u4e2d\u5747\u53d6\u5f97\u4e86\u6210\u529f\u3002\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u4e00\u79cd\u9ad8\u6548\u7684\u8870\u5f31\u8bad\u7ec3\u86cb\u767d\u8d28\u7ec4\u5b66\u751f\u7269\u6807\u5fd7\u7269\u80fd\u591f\u53ef\u9760\u5730\u9884\u6d4b\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u8870\u9000\u3002<\/p>\n\n\n\n<p>\ud83d\udd17 <a href=\"https:\/\/www.cell.com\/cell-reports-methods\/fulltext\/S2667-2375(26)00105-0\">https:\/\/www.cell.com\/cell-reports-methods\/fulltext\/S2667-2375(26)00105-0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u9879\u6765\u81ea Cell \u7684\u6700\u65b0\u7814\u7a76\u53d1\u73b0\uff0c\u901a\u8fc7\u5206\u6790\u8840\u6db2\u4e2d\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\uff0c\u5f00\u53d1\u51fa\u540d\u4e3aProtFI\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u80fd\u6bd4\u4f20\u7edf\u5e74\u9f84\u6307\u6807\u66f4\u7cbe\u51c6\u5730\u9884\u6d4b\u4e2a\u4f53\u8870\u8001\u901f\u5ea6\u548c\u5065\u5eb7\u5bff\u547d\u3002\u7814\u7a76\u56e2\u961f\u57fa\u4e8e4\u4e07\u591a\u4eba\u7684UK Biobank\u6570\u636e\uff0c\u5e76\u5229\u7528\u7b80\u5355\u7684\u7ebf\u6027\u6a21\u578b\u53d1\u73b0\uff0cProtFI\u80fd\u9ad8\u6548\u9884\u6d4b\u8870\u5f31\u6307\u6570\uff08FI\uff09\u548c\u5168\u56e0\u6b7b\u4ea1\u7387\uff0c\u751a\u81f3\u5728\u9884\u6d4b\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u624b\u63e1\u529b\u4e0b\u964d\u548c\u81ea\u8bc4\u5065\u5eb7\u72b6\u51b5\u65b9\u9762\u4f18\u4e8e\u73b0\u6709\u8870\u8001\u751f\u7269\u6807\u5fd7\u7269\u3002\u8fd9\u610f\u5473\u7740\u672a\u6765\u6211\u4eec\u53ef\u4ee5\u901a\u8fc7\u5c11\u91cf\u86cb\u767d\u8d28\u6307\u6807\uff0c\u66f4\u65e9\u8bc6\u522b\u8870\u8001\u98ce\u9669\uff0c\u4ece\u800c\u5b9e\u73b0\u66f4\u65e9\u671f\u3001\u4e2a\u6027\u5316\u7684\u6297\u8870\u8001\u5e72\u9884\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[14],"tags":[],"class_list":["post-977","post","type-post","status-publish","format-standard","hentry","category-featured"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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