{"id":1008,"date":"2026-04-14T12:37:52","date_gmt":"2026-04-14T04:37:52","guid":{"rendered":"https:\/\/longevityforesight.com\/?p=1008"},"modified":"2026-04-14T12:37:55","modified_gmt":"2026-04-14T04:37:55","slug":"peter-attia%e8%a7%a3%e8%af%bb%ef%bc%9a%e7%b2%be%e5%ad%90mirna%e5%bd%b1%e5%93%8d%e5%90%8e%e4%bb%a3%e5%81%a5%e5%ba%b7%ef%bc%8cmrna%e7%96%ab%e8%8b%97%e6%8a%97%e7%99%8c%ef%bc%8c%e5%85%89%e5%a3%b0%e5%88%ba","status":"publish","type":"post","link":"https:\/\/longevityforesight.com\/peter-attia%e8%a7%a3%e8%af%bb%ef%bc%9a%e7%b2%be%e5%ad%90mirna%e5%bd%b1%e5%93%8d%e5%90%8e%e4%bb%a3%e5%81%a5%e5%ba%b7%ef%bc%8cmrna%e7%96%ab%e8%8b%97%e6%8a%97%e7%99%8c%ef%bc%8c%e5%85%89%e5%a3%b0%e5%88%ba\/","title":{"rendered":"Peter Attia\u89e3\u8bfb\uff1a\u7cbe\u5b50miRNA\u5f71\u54cd\u540e\u4ee3\u5065\u5eb7\uff0cmRNA\u75ab\u82d7\u6297\u764c\uff0c\u5149\u58f0\u523a\u6fc0\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff0c\u81ea\u4e3b\u795e\u7ecf\u5931\u8861\u6216\u4e3a\u8870\u8001\u6838\u5fc3\u673a\u5236"},"content":{"rendered":"\n

\u6b22\u8fce\u6765\u5230\u65b0\u4e00\u671f\u7684\u201c\u503c\u5f97\u5206\u4eab\u7684\u7814\u7a76\u201d\u2014\u2014\u672c\u671f\u6c47\u603b\u4e86\u6211\u4eec\u53d1\u73b0\u7684\u6709\u8da3\u4e14\u5e0c\u671b\u4e5f\u80fd\u4e3a\u5176\u4ed6\u4eba\u63d0\u4f9b\u6709\u4ef7\u503c\u89c1\u89e3\u7684\u6700\u65b0\u7814\u7a76\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u7236\u4eb2\u7684\u8fd0\u52a8\u53ef\u4ee5\u901a\u8fc7\u7cbe\u5b50\u5faeRNA\u8d4b\u4e88\u540e\u4ee3\u8010\u529b\u3002<\/a><\/h2>\n\n\n\n

\u6211\u4eec\u4e3a\u4f55\u5bf9\u6b64\u611f\u5174\u8da3\uff1a<\/strong>\u6211\u4eec\u82b1\u8d39\u4e86\u5927\u91cf\u65f6\u95f4\u63a2\u8ba8\u5fc3\u80ba\u529f\u80fd\u5bf9\u4e2a\u4f53\u5bff\u547d\u7684\u76ca\u5904\u3002\u8fd9\u9879\u52a8\u7269\u7814\u7a76\u8fdb\u4e00\u6b65\u62d3\u5c55\u4e86\u8fd9\u4e00\u89c2\u70b9\uff0c\u8868\u660e\u7236\u4eb2\u7684\u8010\u529b\u8bad\u7ec3\u53ef\u4ee5\u8d4b\u4e88\u96c4\u6027\u540e\u4ee3\u5065\u5eb7\u4f18\u52bf\u2014\u2014\u5373\u4f7f\u8fd9\u4e9b\u540e\u4ee3\u81ea\u8eab\u4ece\u672a\u8fdb\u884c\u8fc7\u953b\u70bc\u3002\u00b9\u8fd9\u9879\u7814\u7a76\u7684\u6838\u5fc3<\/sup>\u662fPGC-1\u03b1\uff0c\u5b83\u662f\u4e00\u79cd\u8f6c\u5f55\u5171\u6fc0\u6d3b\u56e0\u5b50\uff0c\u88ab\u5e7f\u6cdb\u8ba4\u4e3a\u662f\u7ebf\u7c92\u4f53\u751f\u7269\u5408\u6210\u548c\u6c27\u5316\u4ee3\u8c22\u7684\u201c\u4e3b\u8c03\u63a7\u56e0\u5b50\u201d \uff0c\u5e76\u4e14\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u4e0e\u8010\u529b\u9002\u5e94\u6027\u76f8\u5173\u3002<\/em><\/p>\n\n\n\n

\u7814\u7a76\u8868\u660e\uff1a<\/strong> <\/strong>\u4e0e\u4e45\u5750\u4e0d\u52a8\u7684\u7236\u4eb2\u6240\u751f\u7684\u540e\u4ee3\u76f8\u6bd4\uff0c\u63a5\u53d7\u8010\u529b\u8bad\u7ec3\u7684\u7236\u4eb2\u6240\u751f\u7684\u7537\u6027\u540e\u4ee3\u5177\u6709\u66f4\u9ad8\u7684\u6700\u5927\u6444\u6c27\u91cf\uff08VO\u2082max\uff09\u3001<\/sub>\u8fd0\u52a8\u8fc7\u7a0b\u4e2d\u66f4\u4f4e\u7684\u4e73\u9178\u79ef\u7d2f\uff0c\u5e76\u4e14\u5728\u529b\u7aed\u524d\u80fd\u591f\u8fbe\u5230\u66f4\u9ad8\u7684\u6700\u5927\u8dd1\u6b65\u901f\u5ea6\u3002\u8fd9\u4e9b\u540e\u4ee3\u6240\u83b7\u5f97\u7684\u76ca\u5904\u5e76\u672a\u4f34\u968f\u4f20\u7edf\u5fc3\u810f\u91cd\u5851\u6307\u6807\uff08\u4f8b\u5982\u5fc3\u810f\u5927\u5c0f\u6216\u5fc3\u810f\u51fa\u8840\u91cf\uff09\u7684\u6539\u53d8\u3002\u76f8\u53cd\uff0c\u8fd9\u79cd\u9002\u5e94\u6027\u53d8\u5316\u662f\u808c\u8089\u7279\u5f02\u6027\u7684\uff1a\u540e\u4ee3\u5c0f\u817f\u808c\u8089\u4e2d\u6c27\u5316\u578b\u808c\u7ea4\u7ef4\u7684\u6bd4\u4f8b\u589e\u52a0\uff0c\u800c\u7cd6\u9175\u89e3\u578b\u808c\u7ea4\u7ef4\u7684\u6bd4\u4f8b\u51cf\u5c11\u3002 <\/p>\n\n\n\n

\u4ed6\u4eec\u968f\u540e\u53d1\u73b0\uff0c\u7531\u4e8e\u8f6c\u57fa\u56e0\u5c0f\u9f20\u808c\u8089\u4e2dPGC-1\u03b1\u8fc7\u8868\u8fbe\uff0c\u5bfc\u81f4\u5176\u751f\u7406\u673a\u80fd\u7c7b\u4f3c\u4e8e\u8fd0\u52a8\u578b\u5c0f\u9f20\uff0c\u56e0\u6b64\u4e45\u5750\u4e0d\u52a8\u7684\u7236\u4eb2\u4e5f\u80fd\u5c06\u8bb8\u591a\u76f8\u540c\u7684\u76ca\u5904\u9057\u4f20\u7ed9\u540e\u4ee3\u3002\u5373\u4f7f\u8fd9\u4e9b\u5c0f\u9f20\u7684\u540e\u4ee3\u6ca1\u6709\u9057\u4f20\u5230\u8f6c\u57fa\u56e0\uff0c\u5b83\u4eec\u4ecd\u7136\u53d7\u76ca\u4e8e\u7236\u4eb2\u7684\u751f\u7406\u673a\u80fd\uff0c\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u8010\u529b\u3001\u5fc3\u80ba\u529f\u80fd\u4ee5\u53ca\u5176\u4ed6\u4e0e\u8fd0\u52a8\u8bad\u7ec3\u52a8\u7269\u76f8\u4f3c\u7684\u6307\u6807\uff0c\u8fd9\u8868\u660ePGC-1\u03b1\u53ef\u80fd\u5728\u8fd0\u52a8\u5bf9\u5e7c\u5d3d\u7684\u76ca\u5904\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u4f5c\u8005\u5c06\u8fd9\u79cd\u4ee3\u9645\u4fe1\u53f7\u8ffd\u6eaf\u5230\u7cbe\u5b50\u4e2d\u643a\u5e26\u7684\u5c0fRNA\u3002\u5c06\u8bad\u7ec3\u6709\u7d20\u7684\u7236\u4eb2\u7684\u7cbe\u5b50\u5c0fRNA\u79fb\u690d\u5230\u91ce\u751f\u578b\u80da\u80ce\u4e2d\uff0c\u8db3\u4ee5\u5728\u540e\u4ee3\u4e2d\u91cd\u73b0\u8010\u529b\u8868\u578b\uff0c\u8868\u660e\u8fd9\u4e9b\u5206\u5b50\u5177\u6709\u56e0\u679c\u4f5c\u7528\u3002\u8010\u529b\u8fd0\u52a8\u548c\u808c\u8089\u7279\u5f02\u6027PGC-1\u03b1\u6fc0\u6d3b\u5747\u80fd\u91cd\u5851\u7cbe\u5b50microRNA\u8c31\uff0c\u4f46\u8fd9\u4e9b\u6539\u53d8\u65e0\u6cd5\u6301\u7eed\u8d85\u8fc7\u4e00\u4ee3\u3002\u6700\u540e\uff0c\u5728\u5c0f\u9f20\u4e2d\u53d1\u73b0\u7684\u51e0\u79cd\u8fd0\u52a8\u53cd\u5e94\u6027\u7cbe\u5b50microRNA\u5728\u63a5\u53d7\u8010\u529b\u8bad\u7ec3\u7684\u4eba\u7c7b\u7cbe\u5b50\u4e2d\u4e5f\u4e0e\u672a\u8bad\u7ec3\u4e2a\u4f53\u7684\u7cbe\u5b50\u5b58\u5728\u5dee\u5f02\uff0c\u8fd9\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u672c\u6587\u6240\u8ff0\u7684\u8868\u89c2\u9057\u4f20\u673a\u5236\u4e0d\u4ec5\u9650\u4e8e\u5355\u4e00\u7269\u79cd\u3002<\/p>\n\n\n\n

\u8fd9\u4e9b\u53d1\u73b0\u5171\u540c\u63d0\u4f9b\u4e86\u53e6\u4e00\u4e2a\u7406\u7531\uff0c\u8ba9\u6211\u4eec\u4f18\u5148\u8003\u8651\u8010\u529b\u8bad\u7ec3\u2014\u2014\u4e0d\u4ec5\u4e3a\u4e86\u4e2a\u4eba\u5065\u5eb7\u548c\u957f\u5bff\uff0c\u800c\u4e14\u8fd8\u6709\u53ef\u80fd\u5f71\u54cd\u4e0b\u4e00\u4ee3\u7684\u4ee3\u8c22\u5065\u5eb7\u72b6\u51b5\u3002<\/p>\n\n\n\n

DOI<\/strong>\uff1a10.1016\/j.cmet.2025.09.003<\/a> <\/p>\n\n\n\n

SARS-CoV-2 mRNA\u75ab\u82d7\u53ef\u589e\u5f3a\u80bf\u7624\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u7684\u654f\u611f\u6027<\/a><\/h2>\n\n\n\n

\u6211\u4eec\u5bf9\u6b64\u611f\u5174\u8da3\u7684\u539f\u56e0\uff1a<\/strong>\u764c\u75c7\u7684\u6cbb\u7597\u5386\u6765\u90fd\u975e\u5e38\u56f0\u96be\u3002\u8fd1\u5e74\u6765\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u836f\u7269\u80fd\u591f\u4ea7\u751f\u663e\u8457\u4e14\u6301\u4e45\u7684\u7597\u6548\uff0c\u4f46\u4ec5\u9650\u4e8e\u90e8\u5206\u60a3\u8005\u3002\u5982\u679c\u4e00\u79cd\u5df2\u83b7\u6279\u51c6\u4e14\u5e7f\u6cdb\u5e94\u7528\u7684\u5e72\u9884\u63aa\u65bd\u80fd\u591f\u63d0\u9ad8ICI\u7684\u7597\u6548\uff0c\u751a\u81f3\u6269\u5927ICI\u7684\u6709\u6548\u4eba\u7fa4\uff0c\u90a3\u4e48\u5b83\u5c06\u5177\u6709\u91cd\u8981\u7684\u4e34\u5e8a\u4ef7\u503c\u3002<\/p>\n\n\n\n

\u7814\u7a76\u7ed3\u679c\uff1a<\/strong>\u8fd9\u9879\u56de\u987e\u6027\u5206\u6790\u663e\u793a\uff0c\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff0cIII\/IV\u671f\uff09\u6216\u9ed1\u8272\u7d20\u7624\uff08IV\u671f\uff09\u60a3\u8005\u5728\u5f00\u59cb\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u6cbb\u7597\u540e100\u5929\u5185\u63a5\u79cdCOVID-19 mRNA\u75ab\u82d7\u53ef\u5ef6\u957f\u751f\u5b58\u671f\u3002<sup> 2<\/sup> <\/sup> 36\u4e2a\u6708\u603b\u751f\u5b58\u671f\u5185\uff0c\u63a5\u79cdCOVID-19 mRNA\u75ab\u82d7\u7684NSCLC\u60a3\u8005\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8649%\uff08HR = 0.51\uff0c95% CI = 0.37\u20130.71\uff09\uff0c\u672a\u63a5\u79cd\u75ab\u82d7\u7684\u60a3\u800536\u4e2a\u6708\u751f\u5b58\u7387\u4e3a30.8%\uff0c\u800c\u63a5\u79cd\u75ab\u82d7\u7684\u60a3\u8005\u4e3a55.7%\u3002\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e5f\u89c2\u5bdf\u5230\u7c7b\u4f3c\u7ed3\u679c\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8663%\uff08HR = 0.37\uff0c95% CI = 0.18\u20130.74\uff09\uff0c\u672a\u63a5\u79cd\u75ab\u82d7\u7684\u60a3\u800536\u4e2a\u6708\u751f\u5b58\u7387\u4e3a44.1%\uff0c\u800c\u63a5\u79cd\u75ab\u82d7\u7684\u60a3\u8005\u4e3a67.6%\u3002\u751f\u5b58\u83b7\u76ca\u4e5f\u4f53\u73b0\u5728\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e0a\uff08\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff1a20.6\u4e2a\u6708 vs. 37.3\u4e2a\u6708\uff1b\u9ed1\u8272\u7d20\u7624\uff1a26.7\u4e2a\u6708 vs. 40\u4e2a\u6708\u65f6\u672a\u8fbe\u5230\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u975emRNA\u6d41\u611f\u6216\u80ba\u708e\u75ab\u82d7\u5e76\u672a\u89c2\u5bdf\u5230\u7c7b\u4f3c\u5173\u8054\uff0c\u8fd9\u8868\u660e\u8fd9\u53ef\u80fd\u5e76\u975e\u666e\u904d\u5b58\u5728\u7684\u201c\u63a5\u79cd\u75ab\u82d7\u7684\u60a3\u8005\u9884\u540e\u66f4\u597d\u201d\u7684\u6548\u5e94\u3002<\/p>\n\n\n\n

\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u7597\u6cd5\u5bf9\u201c\u514d\u75ab\u70ed\u201d\u80bf\u7624\u7597\u6548\u6700\u4f73\uff0c\u8fd9\u610f\u5473\u7740\u60a3\u8005\u5df2\u5bf9\u764c\u75c7\u4ea7\u751f\u6301\u7eed\u7684\uff08\u5c3d\u7ba1\u4e0d\u8db3\u7684\uff09\u514d\u75ab\u53cd\u5e94\u3002PD-L1\u8868\u8fbe\u662f\u8861\u91cf\u8fd9\u79cd\u514d\u75ab\u70ed\u5ea6\u7684\u5e38\u7528\u6307\u6807\u2014\u2014\u8868\u8fbePD-L1\u7684\u80bf\u7624\u7ec6\u80de\u8d8a\u591a\uff0c\u80bf\u7624\u5bf9\u6301\u7eed\u514d\u75ab\u653b\u51fb\u7684\u62b5\u6297\u529b\u5c31\u8d8a\u5f3a\u3002\u4ee4\u4eba\u96be\u4ee5\u7f6e\u4fe1\u7684\u662f\uff0c\u5373\u4f7f\u662f\u9996\u6b21\u6d3b\u68c0\u65f6PD-L1\u7ec6\u80de\u8868\u8fbe<1%\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u2014\u2014\u7531\u4e8e\u57fa\u7ebf\u201c\u514d\u75ab\u51b7\u201d\u800c\u88ab\u8ba4\u4e3a\u4e0d\u9002\u5408\u63a5\u53d7ICI\u6cbb\u7597\u2014\u2014\u5728100\u5929\u5185\u63a5\u79cd\u75ab\u82d7\u540e\uff0c\u6b7b\u4ea1\u98ce\u9669\u4e5f\u964d\u4f4e\u4e8647%\uff08HR = 0.53\uff0c95% CI = 0.36\u20130.78\uff09\u3002\u56e0\u6b64\uff0cmRNA\u75ab\u82d7\u63a5\u79cd\u53ef\u80fd\u65e2\u80fd\u589e\u5f3a<\/em>ICI\u5728NSCLC\u548c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u7684\u7597\u6548\uff0c\u53c8\u80fd<\/em> \u6269\u5927<\/em>ICI\u7684\u7597\u6548\u8303\u56f4\uff0c\u4f7f\u5176\u6db5\u76d6\u201c\u514d\u75ab\u51b7\u201d\u80bf\u7624\u3002<\/p>\n\n\n\n

\u5c3d\u7ba1\u5982\u6b64\uff0c\u8fd9\u9879\u7814\u7a76\u5c5e\u4e8e\u89c2\u5bdf\u6027\u7814\u7a76\u2014\u2014\u60a3\u8005\u5e76\u975e\u7ecf\u8fc7\u7b5b\u9009\u5e76\u968f\u673a\u5206\u914d\u63a5\u79cd\u75ab\u82d7\u6216\u4e0d\u63a5\u79cd\u75ab\u82d7\u2014\u2014\u56e0\u6b64\u6df7\u6742\u56e0\u7d20\u663e\u7136\u662f\u4e00\u4e2a\u503c\u5f97\u5173\u6ce8\u7684\u95ee\u9898\u3002\u5c24\u5176\u662f\u5728\u7f8e\u56fd\uff0c\u65b0\u51a0\u75ab\u82d7\u63a5\u79cd\u7387\u5b58\u5728\u5df2\u77e5\u7684\u201c\u5065\u5eb7\u75ab\u82d7\u6548\u5e94\u201d\uff0c\u5373\u5728\u75ab\u60c5\u671f\u95f4\uff0c\u5065\u5eb7\u4eba\u7fa4\uff08\u4ee5\u53ca\u67d0\u4e9b\u79cd\u65cf\/\u65cf\u88d4\u7fa4\u4f53\uff09\u7684\u75ab\u82d7\u63a5\u79cd\u7387\u66f4\u9ad8\u3002\u6b64\u5916\uff0c\u5728\u9002\u5f53\u63a7\u5236\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u4e2d\uff0c\u5c06\u514d\u75ab\u4f50\u5242\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u4e5f\u66fe\u51fa\u73b0\u5931\u8d25\u6848\u4f8b\u2014\u2014\u5373\u4f7f\u4e34\u5e8a\u524d\u548c\u89c2\u5bdf\u6027\u6570\u636e\u6709\u529b\uff0c\u4e5f \u6ca1\u6709\u4efb\u4f55\u4e00\u79cd\u8054\u5408\u7597\u6cd5\u901a\u8fc7III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/em><\/p>\n\n\n\n

\u636e\u62a5\u9053\uff0c\u76ee\u524d\u6b63\u5728\u8ba1\u5212\u8fdb\u884c III \u671f\u8bd5\u9a8c\uff0c\u6211\u4eec\u5c06\u5bc6\u5207\u5173\u6ce8\u8fd9\u9879\u7814\u7a76\u7684\u8fdb\u5c55\uff0c\u4f46\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u5fc3\u91c7\u7528\u8be5\u7597\u6cd5\u4e4b\u524d\uff0c\u6211\u4eec\u9700\u8981\u770b\u5230\u6765\u81ea\u6b63\u89c4\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7684\u6570\u636e\u3002<\/p>\n\n\n\n

\u4e0d\u8fc7\uff0c\u8fd9\u9879\u7814\u7a76\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u4e00\u4e9b\u75ab\u82d7\u9664\u4e86\u6700\u521d\u7684\u9884\u671f\u76ee\u6807\u5916\uff0c\u8fd8\u80fd\u4ea7\u751f\u5e7f\u6cdb\u7684\u79ef\u6781\u514d\u75ab\u5b66\u6548\u5e94\u2014\u2014\u6b63\u5982\u6211\u4eec\u4e4b\u524d\u8ba8\u8bba\u8fc7\u7684\u5e26\u72b6\u75b1\u75b9\u75ab\u82d7\u4e0e\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d<\/a>\u4e4b\u95f4\u7684\u5173\u7cfb\u4e00\u6837\u3002 <\/p>\n\n\n\n

DOI\uff1a<\/strong>10.1038\/s41586-025-09655-y<\/a><\/p>\n\n\n\n

\u5229\u7528\u5149\u548c\u58f0\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5<\/a><\/h2>\n\n\n\n

\u6211\u4eec\u4e3a\u4f55\u5bf9\u6b64\u611f\u5174\u8da3\uff1a<\/strong>\u76ee\u524d\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u7684\u836f\u7269\u6cbb\u7597\u6548\u679c\u666e\u904d\u4e0d\u5c3d\u5982\u4eba\u610f\uff0c\u4e0d\u4ec5\u5728\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u65b9\u9762\u6548\u679c\u6709\u9650\uff0c\u800c\u4e14\u8fd8\u4f1a\u5e26\u6765\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u98ce\u9669\u3002\u56e0\u6b64\uff0c\u5982\u679c\u80fd\u7814\u53d1\u51fa\u4e00\u79cd\u907f\u514d\u73b0\u6709\u7597\u6cd5\u5e26\u6765\u7684\u8bf8\u591a\u8d1f\u62c5\u7684AD\u6cbb\u7597\u65b9\u6cd5\uff0c\u5c24\u5176\u662f\u4e00\u79cd\u53ef\u4ee5\u5728\u60a3\u8005\u5bb6\u4e2d\u8fdb\u884c\u7684\u6cbb\u7597\uff0c\u90a3\u4e48\u5b83\u5c06\u5177\u6709\u5de8\u5927\u7684\u53d1\u5c55\u6f5c\u529b\u3002<\/p>\n\n\n\n

\u7814\u7a76\u8868\u660e\uff1a<\/strong> OVERTURE\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u4e86\u4e00\u79cd\u4e0d\u540c\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7597\u6cd5\uff1a\u901a\u8fc7\u53ef\u7a7f\u6234\u5f0f\u5934\u6234\u8bbe\u5907\u5728\u5bb6\u4e2d\u8fdb\u884c\u7684\u611f\u5b98\u523a\u6fc0\u3002Cognito\u516c\u53f8<\/sup>\u7684CogTx-001\u5934\u6234\u8bbe\u5907\u4ee540Hz\u7684\u9891\u7387\u53d1\u51fa\u95ea\u5149\u548c\u58f0\u97f3\uff0c\u65e8\u5728\u8bf1\u5bfc\u7528\u6237\u4ea7\u751f\u9ad8\u9891\u8111\u7535\u6ce2\u6a21\u5f0f\u2014\u2014\u8fd9\u79cd\u6a21\u5f0f\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u589e\u5f3a\u795e\u7ecf\u8fde\u63a5\u5e76\u6fc0\u6d3b\u5927\u8111\u7684\u5e9f\u7269\u6e05\u9664\u7cfb\u7edf\u3002\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\uff082:1\u6d3b\u6027\u7ec4\uff1a\u5b89\u6170\u5242\u7ec4\uff0cN=53\uff09\uff0c\u8bd5\u9a8c\u6301\u7eed\u516d\u4e2a\u6708\uff0c\u53d7\u8bd5\u8005\u4e3a50\u5c81\u4ee5\u4e0a\u60a3\u6709\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u6210\u5e74\u4eba\u3002\u53c2\u4e0e\u8005\u6bcf\u5929\u5728\u5bb6\u4e2d\u4f7f\u7528\u8be5\u8bbe\u5907\u4e00\u5c0f\u65f6\uff0c\u4f11\u606f\u65f6\u95ed\u773c\uff1b\u5b89\u6170\u5242\u7ec4\u5219\u4f7f\u7528\u975e40Hz\u7684\u968f\u673a\u6ce2\u52a8\u523a\u6fc0\u3002 <\/p>\n\n\n\n

\u8be5\u5e72\u9884\u63aa\u65bd\u5c55\u73b0\u51fa\u6781\u4f73\u7684\u5b89\u5168\u6027\uff1a\u526f\u4f5c\u7528\u8f7b\u5fae\uff08\u4f8b\u5982\uff0c\u6d3b\u6027\u7ec4\u51fa\u73b0\u5934\u75db\u548c\u8033\u9e23\uff09\uff0c\u672a\u89c2\u5bdf\u5230\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u5b89\u5168\u95ee\u9898\uff0c\u4e14\u53c2\u4e0e\u8005\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u5747\u575a\u6301\u4f7f\u7528\u8be5\u8bbe\u5907\uff08\u4e24\u7ec4\u7684\u6bcf\u65e5\u4f9d\u4ece\u6027\u5747\u8d85\u8fc7 80%\uff09\u3002\u6b64\u5916\uff0c\u8fd8\u51fa\u73b0\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u4e34\u5e8a\u83b7\u76ca\u4fe1\u53f7\u2014\u2014\u5c24\u5176\u662f\u5728\u65e5\u5e38\u751f\u6d3b\u529f\u80fd\u65b9\u9762\uff0c\u63a5\u53d7\u6d3b\u6027\u6cbb\u7597\u7684\u60a3\u8005\u5728\u516d\u4e2a\u6708\u5185\u65e5\u5e38\u751f\u6d3b\u6d3b\u52a8\u80fd\u529b\u4e0b\u964d\u901f\u5ea6\u6bd4\u63a5\u53d7\u5b89\u6170\u5242\u6cbb\u7597\u7684\u60a3\u8005\u6162 84%\u3002\u601d\u7ef4\u548c\u8bb0\u5fc6\u65b9\u9762\u7684\u7ed3\u679c\u5219\u559c\u5fe7\u53c2\u534a\uff1a\u4e00\u9879\u5e7f\u6cdb\u4f7f\u7528\u7684\u7b5b\u67e5\u6d4b\u8bd5\uff08\u7b80\u6613\u7cbe\u795e\u72b6\u6001\u68c0\u67e5\uff0c\u7b80\u79f0 MMSE\uff09\u663e\u793a\u75c7\u72b6\u8fdb\u5c55\u901f\u5ea6\u6162 74%\uff0c\u800c\u53e6\u5916\u4e24\u9879\u8ba4\u77e5\u6d4b\u8bd5\u5219\u663e\u793a\u4e24\u7ec4\u4e4b\u95f4\u65e0\u663e\u8457\u5dee\u5f02\u3002<\/p>\n\n\n\n

\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u9ad8\u4f9d\u4ece\u6027\u81f3\u5173\u91cd\u8981\uff0c\u4f46\u4e5f\u6781\u96be\u5b9e\u73b0\u3002\u7136\u800c\uff0c\u7597\u6548\u6307\u6807\u4ecd\u6709\u5f85\u6539\u8fdb\u2014\u2014\u8111\u5185\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u805a\u96c6\u4f53\u672a\u89c1\u53d8\u5316\uff0c\u8ba4\u77e5\u6d4b\u8bd5\u7ed3\u679c\u4e5f\u76f8\u4e92\u77db\u76fe\uff0c\u4f46\u65e5\u5e38\u751f\u6d3b\u6d3b\u52a8\u80fd\u529b\u4e0e\u8111\u5bb9\u91cf\u589e\u52a0\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u6b63\u76f8\u5173\u6027\u3002\u6362\u8a00\u4e4b\uff0c\u76ee\u524d\u5df2\u6709\u4e00\u4e9b\u79ef\u6781\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\uff0c\u4f46\u5c1a\u4e0d\u8db3\u4ee5\u5728\u5b8c\u6210\u5e76\u516c\u5e03III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u4e4b\u524d\u91c7\u53d6\u4efb\u4f55\u884c\u52a8\u3002<\/p>\n\n\n\n

doi: <\/strong>10.3389\/fneur.2024.1343588<\/a><\/p>\n\n\n\n

\u4ea4\u611f\u795e\u7ecf-\u526f\u4ea4\u611f\u795e\u7ecf\u7cfb\u7edf\u5931\u8c03\u4e0e\u8870\u8001\u7406\u8bba<\/a><\/h2>\n\n\n\n

\u6211\u4eec\u4e3a\u4f55\u5bf9\u6b64\u611f\u5174\u8da3\uff1a<\/strong>\u8870\u8001\u662f\u5927\u591a\u6570\u6162\u6027\u75be\u75c5\u7684\u4e3b\u8981\u98ce\u9669\u56e0\u7d20\uff0c\u7136\u800c\u9a71\u52a8\u8870\u8001\u7684\u751f\u7269\u5b66\u673a\u5236\u4ecd\u77e5\u4e4b\u751a\u5c11\u3002\u5c3d\u7ba1\u4eba\u4eec\u63d0\u51fa\u4e86\u8bb8\u591a\u8870\u8001\u7406\u8bba\uff0c\u6bcf\u79cd\u7406\u8bba\u90fd\u5f3a\u8c03\u751f\u7269\u5b66\u7684\u4e0d\u540c\u65b9\u9762\uff0c\u4f46\u6ca1\u6709\u4e00\u79cd\u7406\u8bba\u80fd\u591f\u63d0\u4f9b\u5b8c\u6574\u7684\u89e3\u91ca\u3002\u56e0\u6b64\uff0c\u80fd\u591f\u66f4\u6df1\u5165\u5730\u4e86\u89e3\u8870\u8001\u8fc7\u7a0b\u7684\u65b0\u7406\u8bba\uff0c\u5305\u62ec\u90a3\u4e9b\u6700\u521d\u5e76\u672a\u5728\u8870\u8001\u7279\u5f81\u4e2d\u63d0\u51fa\u7684\u673a\u5236\uff0c\u5177\u6709\u91cd\u8981\u7684\u610f\u4e49\u3002\u6b64\u7c7b\u7406\u8bba\u6846\u67b6\u6709\u52a9\u4e8e\u9610\u660e\u54ea\u4e9b\u7ec6\u80de\u8fc7\u7a0b\u9a71\u52a8\u7740\u8eab\u4f53\u548c\u8ba4\u77e5\u80fd\u529b\u7684\u4e0b\u964d\uff0c\u4ece\u800c\u4e3a\u5f00\u53d1\u65e8\u5728\u540c\u65f6\u5ef6\u7f13\u6216\u9884\u9632\u591a\u79cd\u75be\u75c5\u7684\u5e72\u9884\u63aa\u65bd\u63d0\u4f9b\u4fe1\u606f\uff0c\u800c\u4e0d\u662f\u5355\u72ec\u6cbb\u7597\u6bcf\u79cd\u75be\u75c5\u3002 <\/p>\n\n\n\n

\u4ed6\u4eec\u8ba8\u8bba\u7684\u5185\u5bb9\uff1a<\/strong>\u8fd9\u7bc7\u7acb\u573a\u6587\u7ae0\u63d0\u51fa\uff0c\u4ea4\u611f\u795e\u7ecf\u7cfb\u7edf\uff08SNS\uff09\u548c\u526f\u4ea4\u611f\u795e\u7ecf\u7cfb\u7edf\uff08PNS\uff09\u7684\u5931\u8c03\u662f\u8870\u8001\u8fc7\u7a0b\u7684\u7edf\u4e00\u6846\u67b6\u3002<sup> 4<\/sup><\/sup> SNS \u548c PNS \u662f\u81ea\u4e3b\u795e\u7ecf\u7cfb\u7edf\u7684\u4e24\u5927\u5206\u652f\uff0c\u81ea\u4e3b\u795e\u7ecf\u7cfb\u7edf\u8c03\u8282\u5fc3\u7387\u3001\u547c\u5438\u548c\u65b0\u9648\u4ee3\u8c22\u7b49\u975e\u81ea\u4e3b\u751f\u7406\u529f\u80fd\u3002SNS \u4ecb\u5bfc\u201c\u6218\u6597\u6216\u9003\u8dd1\u201d\u53cd\u5e94\uff0c\u800c PNS \u4e3b\u8981\u901a\u8fc7\u8ff7\u8d70\u795e\u7ecf\u652f\u6301\u201c\u4f11\u606f\u548c\u6d88\u5316\u201d\u529f\u80fd\uff0c\u4fc3\u8fdb\u6062\u590d\u548c\u4f53\u5185\u5e73\u8861\u3002\u4f5c\u8005\u8ba4\u4e3a\uff0c\u6162\u6027SNS<\/em>\u6fc0\u6d3b\u4f1a\u5bfc\u81f4\u591a\u79cd\u8870\u8001\u7279\u5f81\uff0c\u800c PNS \u7684\u6fc0\u6d3b\u5219\u53ef\u4ee5\u5e73\u8861\u8fd9\u79cd\u6fc0\u6d3b\u3002\u4ee5\u6162\u6027\u708e\u75c7\uff08\u201c\u708e\u75c7\u8870\u8001\u201d\uff09\u4e3a\u4f8b\uff1aSNS \u5728\u635f\u4f24\u6216\u75be\u75c5\u53cd\u5e94\u4e2d\u88ab\u6fc0\u6d3b\uff0c\u523a\u6fc0\u4fc3\u708e\u5206\u5b50\u7684\u4ea7\u751f\u4ee5\u4fee\u590d\u635f\u4f24\uff1b\u800c\u5728\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u5e73\u8861\u7684 PNS \u6709\u52a9\u4e8e\u708e\u75c7\u53cd\u5e94\u7684\u6d88\u9000\uff0c\u9632\u6b62\u6301\u7eed\u7684\u708e\u75c7\u72b6\u6001\u3002<\/p>\n\n\n\n

\u4f5c\u8005\u5c06\u4ea4\u611f\u795e\u7ecf-\u526f\u4ea4\u611f\u795e\u7ecf\u529f\u80fd\u5931\u8c03\u662f\u8870\u8001\u7684\u57fa\u7840\u8fd9\u4e00\u7406\u8bba\u6269\u5c55\u5230\u8870\u8001\u7684\u5176\u4ed6\u51e0\u4e2a\u6807\u5fd7\u6027\u7279\u5f81\uff0c\u5305\u62ec\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u548c\u8868\u89c2\u9057\u4f20\u6539\u53d8\u3002\u7406\u8bba\u4e0a\uff0c\u5bf9\u4e8e\u6bcf\u4e00\u79cd\u8870\u8001\u7279\u5f81\uff0c\u5b8c\u6574\u7684\u526f\u4ea4\u611f\u795e\u7ecf\u7cfb\u7edf\u6d3b\u52a8\u90fd\u80fd\u62b5\u6d88\u8fd9\u4e9b\u4e0e\u538b\u529b\u76f8\u5173\u7684\u8fc7\u7a0b\uff0c\u5e76\u6062\u590d\u751f\u7406\u5e73\u8861\u3002\u56e0\u6b64\uff0c\u6839\u636e\u8fd9\u4e00\u6a21\u578b\uff0c\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u795e\u7ecf\u7cfb\u7edf\u4f1a\u9010\u6e10\u5411\u66f4\u5f3a\u7684\u4ea4\u611f\u795e\u7ecf\u529f\u80fd\u53d1\u5c55\uff0c\u5bfc\u81f4\u538b\u529b\u901a\u8def\u6301\u7eed\u6fc0\u6d3b\uff0c\u4ece\u800c\u52a0\u5267\u8eab\u4f53\u548c\u8ba4\u77e5\u80fd\u529b\u7684\u8870\u9000\u3002 <\/p>\n\n\n\n

\u5982\u679c\u6b63\u786e\u7684\u8bdd\uff0c\u8fd9\u4e00\u63d0\u51fa\u7684\u7406\u8bba\u63d0\u4f9b\u4e86\u4e00\u79cd\u65e8\u5728\u6fc0\u6d3b\u5468\u56f4\u795e\u7ecf\u7cfb\u7edf\uff08\u4f8b\u5982\uff0c\u8ff7\u8d70\u795e\u7ecf\u523a\u6fc0\uff09\u7684\u6f5c\u5728\u6cbb\u7597\u65b9\u6cd5\uff0c\u4f7f\u5176\u6210\u4e3a\u4e00\u4e2a\u7279\u522b\u6709\u5438\u5f15\u529b\u7684\u524d\u666f\u3002 <\/p>\n\n\n\n

DOI\uff1a<\/strong>10.1038\/s41514-025-00293-2<\/a><\/p>\n\n\n\n

\ud83d\udd17 https:\/\/peterattiamd.com\/research-worth-sharing-april-2026\/<\/p>\n","protected":false},"excerpt":{"rendered":"

Peter Attia\u53d1\u5e03\u7684\u56db\u6708\u7814\u7a76\u7cbe\u9009\u4e2d\uff0c\u6709\u56db\u9879\u63a2\u7d22\u6027\u53d1\u73b0\u503c\u5f97\u5173\u6ce8\uff1a\u5176\u4e2d\uff0c\u7236\u4eb2\u7684\u8fd0\u52a8\u72b6\u6001\u901a\u8fc7\u7cbe\u5b50\u5fae\u5c0fRNA\u5f71\u54cd\u540e\u4ee3\u5065\u5eb7\uff0c\u63ed\u793a\u4e86\u8868\u89c2\u9057\u4f20\u5bf9\u5065\u5eb7\u5bff\u547d\u7684\u65b0\u89c6\u89d2\uff1bmRNA\u65b0\u51a0\u75ab\u82d7\u6216\u80fd\u589e\u5f3a\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff0c\u4e3a\u6297\u764c\u4e0e\u957f\u5bff\u7ed3\u5408\u63d0\u4f9b\u65b0\u9014\u5f84\uff1b\u4f4e\u98ce\u9669\u7684\u5149\u58f0\u523a\u6fc0\u6cbb\u7597\u6709\u671b\u5e94\u7528\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff0c\u76f4\u63a5\u5173\u8054\u8ba4\u77e5\u5065\u5eb7\uff1b\u6700\u91cd\u8981\u7684\u662f\uff0c\u81ea\u4e3b\u795e\u7ecf\u7cfb\u7edf\u5931\u8861\u88ab\u63d0\u51fa\u4f5c\u4e3a\u8870\u8001\u7684\u7edf\u4e00\u7406\u8bba\uff0c\u8fd9\u4e00\u673a\u5236\u5c42\u9762\u7684\u53d1\u73b0\u53ef\u80fd\u4e3a\u7406\u89e3\u548c\u5e72\u9884\u8870\u8001\u63d0\u4f9b\u66f4\u6df1\u5c42\u6b21\u7684\u7a81\u7834\uff0c\u5bf9\u5168\u751f\u547d\u5468\u671f\u7684\u5065\u5eb7\u7ba1\u7406\u5177\u6709\u6f5c\u5728\u7684\u6307\u5bfc\u610f\u4e49\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15],"tags":[],"class_list":["post-1008","post","type-post","status-publish","format-standard","hentry","category-news"],"acf":[],"yoast_head":"\nPeter Attia\u89e3\u8bfb\uff1a\u7cbe\u5b50miRNA\u5f71\u54cd\u540e\u4ee3\u5065\u5eb7\uff0cmRNA\u75ab\u82d7\u6297\u764c\uff0c\u5149\u58f0\u523a\u6fc0\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff0c\u81ea\u4e3b\u795e\u7ecf\u5931\u8861\u6216\u4e3a\u8870\u8001\u6838\u5fc3\u673a\u5236 - Longevity Foresight<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longevityforesight.com\/peter-attia\u89e3\u8bfb\uff1a\u7cbe\u5b50mirna\u5f71\u54cd\u540e\u4ee3\u5065\u5eb7\uff0cmrna\u75ab\u82d7\u6297\u764c\uff0c\u5149\u58f0\u523a\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Peter 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